Product Name :
NUDC Recombinant Rabbit Monoclonal Antibody [JE50-74]
Predicted band size :
Observed band size :
Synonyms:
HNUDC antibody MNUDC antibody MNUDC protein antibody NPD011 antibody Nuclear distribution C homolog antibody Nuclear distribution gene C (A.nidulans) homolog antibody Nuclear distribution gene C homolog antibody Nuclear distribution gene C homolog (A. nidulans) antibody Nuclear distribution protein C homolog antibody Nuclear migration protein nudC antibody 展开
Function :
NUDC (nuclear distribution gene C homolog, A. nidulans), also known as HNUDC, MNUDC or NPD011, is a ubiquitously expressed protein that is conserved from fungus to human. Highly expressed in proliferating cells, NUDC localizes to the cytoplasm and nucleus, contains a CS domain and participates in neurogenesis, mitosis, nuclear migration and cytokinesis. At the onset of mitosis, NUDC is phosphorylated by Plk. This modification of NUDC is required for proper mitotic spindle formation, chromosome separation during mitosis, cytokinesis and cell proliferation. In neurons and fibroblasts, NUDC forms a complex with LIS1 that localizes to the microtubule network and microtubule-organizing center and facilitates nuclear movement and transport in migrating neurons. In addition, the NUDC/LIS1 complex can associate with the minus-end directed Dynein/Dynactin motor complex and, together, these complexes cooperate in the regulation of cytokinesis.G0-C14 site
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human NUDC aa 207-331 / 331.Nα,Nα-Bis(carboxymethyl)-L-lysine Chemical name
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE50-74
RRID:
AB_3070985
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33634719 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 38 kDa
Positive control :
K562 cell lysates, PC-3M cell lysates, U937 cell lysates, rat brain tissue, human tonsil tissue, human colon carcinoma tissue, human gastric carcinoma tissue, mouse brain tissue, F9.