Product Name :
PIWIL4 Mouse Monoclonal Antibody [B11-G9]
Predicted band size :
Observed band size :
Synonyms:
DKFZp686P01248 antibody FLJ36156 antibody HILI 2 antibody HILI2 antibody HIWI 2 antibody HIWI2 antibody Miwi 2 protein antibody Miwi2 antibody PIWI antibody Piwi like 2 antibody 展开
Function :
PIWIL4 (PIWI-like protein 4), also known as HIWI2 is a 852 amino acid protein that belongs to the argonaute family. PIWIL4 contains one PAZ domain and one PIWI domain and is essential for the maintenance of germline stem cells. PIWIL4 is a cytoplasmic protein that is expressed in adult testis. It regulates spermatogenesis and primordial germ cell production and has an essential role in meiotic differentiation of spermatocytes and in self-renewal of spermatogonial stem cells. PIWIL4-null mice are of normal size and weight and have the expected life span. Homozygous PIWIL4-null females are fertile and have no obvious defects. However, PIWIL4-deficient males are infertile and show a meiotic progression defect in early prophase of meiosis I and progressive loss of germ cells with age. Mutant males show elevated expression of LINE-1 and intracisternal A particle (IAP) element transcripts in germ cell lineages. The gene encoding PIWIL4 maps to human chromosome 11.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein
Species reactivity:
Human
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
B11-G9
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.891724-25-7 structure
Storage buffer solution:
Purified antibody in PBS with 0.Formula of Propargyl-PEG1-NH2 05% sodium azide.PMID:33427568
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
97 kDa
Positive control :
Human PIWIL4 recombinant protein, PIWIL4-hIgGFc transfected HEK293 cell lysate, PC-3, PANC-1 cell lysate, human ovarian cancer tissue, human rectum cancer tissue, Hela.